Memory-making involves extensive DNA breaking - MIT News
2021年7月14日 · To provide access to genes needed for the encoding and storage of memories, brain cells snap open their DNA, breaking both strands. A new study finds this happens more …
Memories are made by breaking DNA — and fixing it - Nature
2024年3月27日 · When a long-term memory forms, some brain cells experience a rush of electrical activity so strong that it snaps their DNA. Then, an inflammatory response kicks in, …
Memory making involves extensive DNA breaking
2021年7月6日 · To quickly express genes needed for learning and memory, brain cells snap both strands of DNA in many more places and cell types than previously realized, a new study shows
Meiotic DNA breaks drive multifaceted mutagenesis in the
We uncovered new mutational signatures and footprints relative to break sites, which implicate unexpected biochemical processes and error-prone DNA repair mechanisms, including …
Double-strand DNA breaks - Latest research and news | Nature
2024年11月1日 · A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation.
DNA double-strand break signaling and human disorders
2010年11月5日 · DNA double-strand breaks (DSBs) are among the most serious and lethal types of DNA damage, as a single DSB is sufficient to kill a cell or disturb its genomic integrity [1]. …
Breaking DNA | Science - AAAS
2016年2月26日 · Topoisomerases create transient breaks in DNA to change DNA supercoiling or untangle intertwined DNA duplexes, thereby facilitating processes such as transcription or …
Memory making involves extensive DNA breaking - ScienceDaily
2021年7月6日 · "Clearly memory formation is an urgent priority for healthy brain function but these new results showing that several types of brain cells break their DNA in so many places to …
Double-Strand DNA Breaks | Learn Science at Scitable - Nature
By-products of the cell's own metabolism such as reactive oxygen species can damage DNA bases and cause lesions that can block progression of replication. The result is double-strand …
Structure and repair of replication-coupled DNA breaks | Science
2024年6月20日 · We show that replication fork collapse at leading-strand nicks generates resected single-ended double-strand breaks (seDSBs) that are repaired by homologous …