胞外结构域？ 胞内结构域？ - 知乎 - 知乎专栏
2023年7月29日 · 胞内结构域： 胞内结构域是蛋白质分子中存在于细胞内的特定区域，通常与细胞内的信号传导、调节、催应等功能相关。 这些结构域通常通过 细胞膜 或细胞器膜上的蛋白质 …
The cytoplasmic domain is essential for transport function of the ...
2016年1月15日 · Large cytoplasmic domains (CD) are a common feature among integral membrane proteins. In virtually all cases, these CD have a function (e.g., binding cytoskeleton …
Binding of the cytoplasmic domain of CD28 to the plasma …
2016年7月26日 · Our studies show that the cytoplasmic domains of CD28, such as those of the CD3ε and CD3ζ chains, are bound to the inner leaflet of the plasma membrane. Previous …
Homodimerized cytoplasmic domain of PD-L1 regulates its …
2022年8月30日 · By using genetically incorporated crosslinkers, we showed that full length PD-L1 forms homodimers and tetramers in living cells. Importantly, the homodimerized intracellular …
The First 3D Model of the Full-Length KIT Cytoplasmic Domain …
2020年3月25日 · We communicate the first structural model of the full-length RTK KIT cytoplasmic domain, a crucial target for cancer therapy. This model was achieved by …
Targeting the PD-L1 cytoplasmic domain and its regulatory …
2023年11月22日 · Recently, the small cytoplasmic domain of PD-L1 has been reported to regulate PD-L1 stability and function through multiple pathways. Therefore, the intracellular …
Transmembrane and cytoplasmic domains in integrin activation …
Key components of this control mechanism are the transmembrane and cytoplasmic domains of the α and β subunits. These domains are believed to interact, holding the integrin in the …
Genome characteristics at the borders - Nature
2025年1月6日 · As the command centre of eukaryotic cells, the nucleus is partitioned from the cytoplasm by the nuclear envelope, a structure comprising a bilayer lipid membrane and the …
Bidirectional Transmembrane Signaling by Cytoplasmic Domain ... - Science
2003年9月19日 · Here, we use fluorescence resonance energy transfer (FRET) to investigate the spatial proximity of α L and β 2 cytoplasmic domains in living cells. These studies provide …
CAR-T design: Elements and their synergistic function
2020年8月1日 · We provide a comprehensive review of recent research on CAR design and systematically evaluate design aspects of the four major modules of CAR structure: the ligand …