Cyclosporin microemulsion (Neoral). A pharmacoeconomic review ...
Cyclosporin microemulsion (Neoral) is a self-emulsifying preconcentrate of cyclosporin which is more rapidly and consistently absorbed than the original oil-based formulation of cyclosporin (standard formulation; Sandimmun, Sandimmune).
Microemulsion formulation of cyclosporin (Sandimmun Neoral ...
2000年2月1日 · To compare the safety, tolerability and efficacy of the new oral microemulsion formulation of cyclosporin A (CyA; Sandimmun Neoral ®) and the original CyA formulation (Sandimmun ®), in patients with severe active rheumatoid arthritis (RA), over a 12‐month period.
Neoral® is an oral formulation of cyclosporine that immediately forms a microemulsion in an aqueous environment. Cyclosporine, the active principle in Neoral®, is a cyclic polypeptide...
Cyclosporin: an updated review of the pharmacokinetic ...
Cyclosporin microemulsion is at least as effective as the oil-based formulation in renal, liver and heart transplant recipients, with trends towards decreased incidence of acute rejection with the microemulsion formulation in some (statistically significant in a few) trials.
Cyclosporin. A review of the pharmacokinetic properties ...
The microemulsion formulation may be of particular benefit in patients who show poor absorption of cyclosporin from the standard oral formulation, such as liver transplant recipients with biliary diversion or cholestasis.
Cyclosporin Microemulsion (Neoral®)† - Springer
2012年12月3日 · Cyclosporin microemulsion (Neoral®) is a self-emulsifying preconcentrate of cyclosporin which is more rapidly and consistently absorbed than the original oil-based formulation of cyclosporin (standard formulation; Sandimmun®, Sandimmune ®).
A New Microemulsion Formulation of Cyclosporin | Clinical ...
2012年11月22日 · Recently, a new galenic formulation of cyclosporin was introduced, ‘Neoral’, which is a water-free microemulsion of cyclosporin. The microemulsion creates micelles which are absorbed in the small bowel without the presence of bile.
Cyclosporin | Drugs - Springer
2012年10月13日 · This new formulation is a microemulsion preconcentrate which, on contact with gastrointestinal fluids, readily produces a microemulsion that mimics the mixed micellar phase of absorption seen with the standard oral formulation. The microemulsion system is stable, releases cyclosporin quickly, and can be diluted without causing precipitation.
Cyclosporine microemulsion increases drug exposure and ...
1998年9月1日 · The new oral microemulsion formulation of cyclosporine (Neoral®) possesses superior pharmacokinetics to the conventional formulation, Sandimmun® (SIM), providing more complete and predictable absorption, and less pharmacokinetic variability.
These results suggest that the superior pharmaco-kinetic characteristics of the microemulsion formulation of cyclo-sporine lead to more efficient immunosuppression during the first critical months after transplantation, without a deleterious impact on clinical safety.