Biomarker modeling of Alzheimer’s disease using PET-based
2022年4月25日 · We used PET-based Braak stage to model the trajectories of amyloid-β, phosphorylated tau (pTau) in cerebrospinal fluid (pTau181, pTau217, pTau231 and pTau235) …
Cortical microstructural associations with CSF amyloid and pTau
2023年12月13日 · In this study, we evaluated the effect of CSF phosphorylated tau 181 (pTau 181) and β-amyloid 1-42 (Aβ 1–42) burden, as well as their ratio, on cortical NODDI and MAP …
Early and selective localization of tau filaments to glutamatergic ...
2024年6月11日 · Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of paired helical filaments is a major hallmark of Alzheimer’s disease. Subcellular …
Early and selective localization of tau filaments to glutamatergic ...
2024年6月11日 · At stage I, ptau is observed in the entorhinal cortex (EC), followed by the hippocampus at stage II. By stage III, ptau is located in other areas of the medial temporal …
Phosphorylation of different tau sites during progression of …
2018年6月29日 · Our results suggest that the ptau burden in the isocortex is comparable between all analyzed ptau sites when using a quantitative approach while levels of ptau at Tyr18 or …
The influence of APOEε4 on the pTau interactome in sporadic
2024年5月21日 · A characterization of Tau pathology in the frontal cortex showed a higher density of plaque-associated neuritic crowns, made of dystrophic axons and synapses, in APOEε4 …
Spread of pathological human Tau from neurons to …
2022年11月11日 · Intracellular aggregation of hyperphosphorylated Tau (pTau) in the brain is associated with cognitive and motor impairments, and ultimately neurodegeneration. We …
Emerging signs of Alzheimer-like tau hyperphosphorylation and ...
2024年9月29日 · We first examined the level of phosphorylated tau (pTau) in the hippocampus and medial entorhinal cortex (MEC), since these regions play pivotal roles in the development …
Aggregate-selective removal of pathological tau by clustering
2024年8月29日 · Frontal cortex hemispheres from mice treated with R-Nb F8-2 AAV1/2 were homogenized and probed for pTau (AT100, pThr 212, and pSer 214) and total tau protein, …
Phosphorylated tau as a candidate biomarker for amyotrophic lateral ...
Main outcomes and measures: The CSF level of tau phosphorylated at threonine 181 (ptau) and ratio of ptau to total tau (ttau). Results: Using a cross-validation prediction procedure, we …