Chromatin loops in gene regulation - PMC - PubMed Central (PMC)
What are chromatin loops? A chromatin loop occurs when stretches of genomic sequence that lie on the same chromosome (configured in cis) are in closer physical proximity to each other …
Landscape of cohesin-mediated chromatin loops in the human …
2020年7月29日 · To integrate gene expression and histone data, we generated a map of genes to loops as follows: ‘All’ (a gene was assigned to any loop within 1 kb of its start or end …
Evolution and function of chromatin domains across the tree of life
1 天前 · b, The loop extrusion mechanism drives chromatin domain formation, especially in vertebrates. Loop-extruding factors such as the SMC complex cohesin (and condensin in …
Keeping chromatin in the loop (s) - Nature
2021年1月27日 · Chromatin looping compacts these polymers, helps genome organization by the formation of enhancer–promoter and other interactions, and emerges when genes are highly …
From compartments to loops: understanding the unique chromatin ...
2024年5月23日 · We integrate findings from recent studies to elucidate the characteristics of various levels of chromatin organization, from differential compartmentalization and …
Dynamics of CTCF- and cohesin-mediated chromatin looping
2022年4月14日 · Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation and …
Chromatin extrusion explains key features of loop and domain ... - PNAS
2015年10月23日 · Initially, its subunits are bound to nearby DNA elements, forming a tiny chromatin loop. Next, DNA is extruded through the subunits such that the two tethered …
ChromLoops: a comprehensive database for specific protein …
2022年10月16日 · It is necessary to build a chromatin loop database to integrate and analyze loop results and annotate the genes and regions involved in the interactions. This will help …
Chromatin loops in gene regulation - ScienceDirect
2009年1月1日 · Notably, the SATB1 ChIP-loop assay and the unbiased 3C assay produced very similar findings suggesting that SATB1 contributes to the anchoring of most if not all …
Structures considered key to gene expression are ... - MIT News
2022年4月14日 · MIT researchers have discovered that chromatin spends most of its time in a partially looped state (middle). Fully formed loops (right) occur only three to six percent of the …
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