Cancer vaccines: the next immunotherapy frontier - Nature
2022年8月23日 · Therefore, by activating tumor antigen-loaded DCs, cancer vaccines may induce immune responses against a large array of intracellular antigens.
Therapeutic cancer vaccines: advancements, challenges and …
2023年12月13日 · Recently, therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens, including tumor-associated antigens and tumor-specific antigens.
Selecting Target Antigens for Cancer Vaccine Development
Cancer vaccines are based on tumor antigens expressed in the context of Major Histocompatibility Complex (MHC) molecules able to elicit a strong tumor-specific CTL response, which may result in the killing of tumor cells and cancer regression.
Cancer vaccine - Wikipedia
Cancer vaccines seek to target a tumor-specific antigen as distinct from self-proteins. Selection of the appropriate adjuvant to activate antigen-presenting cells to stimulate immune responses, is required.
Rethinking Antigen Source: Cancer Vaccines Based on Whole …
2023年5月31日 · Autologous tumor cells are the best antigen source to prepare cancer vaccines, and they carry a variety of specific tumor antigens; therefore, whole tumor cell lysates are an ideal antigen source to be used as antigens in cancer vaccines.
Cancer vaccines as promising immuno-therapeutics: platforms …
2022年3月18日 · The ideal antigen for a cancer vaccine should be highly immunogenic, explicitly expressed in all cancer cells (not in normal cells) and necessary for the survival of cancer cells . Tumor antigens can be divided into TAAs and TSAs.
Rethinking Antigen Source: Cancer Vaccines Based on Whole …
Three components are critical in cancer vaccines: antigen, adjuvant, and formulation. Among them, antigen is the most essential component in cancer vaccine. Selecting antigens is the most important step in designing vaccines and cancer cell is the best antigen source for preparing cancer vaccines.
Cancer vaccines: shared tumor antigens return to the spotlight
2020年10月30日 · TAA vaccines must overcome central and acquired tolerance, limiting the magnitude of induced T-cell responses. Many vaccine platforms have proven to be suboptimal, inducing weak and/or...
Cancer Vaccines: Antigen Selection Strategy - PubMed
2021年1月25日 · Unlike traditional cancer therapies, cancer vaccines (CVs) harness a high specificity of the host's immunity to kill tumor cells. CVs can train and bolster the patient's immune system to recognize and eliminate malignant cells by enhancing immune cells' identification of antigens expressed on cancer …
Cancer Vaccines: The Types, How They Work, and Which Cancers …
Therapeutic cancer vaccines expose your immune system to molecules, called antigens, that are associated with a specific type of cancer. These vaccines enable the immune system to recognize and destroy the cancer cells. Therapeutic cancer vaccines consist of specific antigens combined with another immune system trigger called an adjuvant.