Tissue-Resident Memory T Cells in Skin Diseases: A Systematic …
2021年8月20日 · Tissue-resident memory T cells (TRMs) are a subset of memory T cells. TRMs can be of either cluster of differentiation (CD)4 + or CD8 + lineage. CD4 + T cells assist in …
Tissue resident memory T cells in the respiratory tract
2021年10月20日 · The co-expression of CD69 and CD103 can be used to identify CD8 + Trm in the lung and nose in both mice and humans 15,19, whereas lung CD4 + Trm express CD69, …
Location, location, location: Tissue resident memory T cells in mice ...
In healthy human skin, the majority of TRM are dermal CD4 + CD69 + CD103 – cells, with the epidermis containing mixed populations of CD4 + and CD8 + TRM expressing CD103 . These …
CD49a Expression Defines Tissue-Resident CD8 - Cell Press
Tissue-resident memory T (Trm) cells provide localized adaptive immunity in peripheral tissues. Cheuk et al. identify cytotoxic CD49a+CD8+ Trm cells and IL-17-producing CD49a−CD8+ Trm …
Resident Memory T Cells in Autoimmune Skin Diseases
2021年5月2日 · Both CD4+ and CD8+ TRM have been described in skin and other tissues including the mucosa, lung, brain, GI tract and pancreas (1–5). Because of the very different …
T cells and the skin: from protective immunity to inflammatory skin ...
2019年4月16日 · Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T RM) cells, which remain in skin for …
Tissue-Resident Memory T Cells: Immunity - Cell Press
2014年12月18日 · These data suggest that prolonged antigen stimulation might induce CD4 + and CD8 + Trm cells within SLOs. There is also evidence for Trm cells in SLOs in the putative …
Human skin-resident CD8 - Cell Press
2023年6月2日 · In barrier tissues like the skin, cytotoxic CD8+CD103+CD49a+ tissue-resident memory (TRM) cells provide localized immunity. Zitti et al. show that human epidermal TRM …
Tissue-resident memory T cells in the skin - Springer
2020年1月27日 · Tissue-resident memory T (TRM) cells are a newly described subset of memory T cells. The best characterized TRM cells are CD8+ and express CD103 and CD69. These …
Skin infection generates non-migratory memory CD8+ TRM cells …
2012年2月29日 · Here we show in mice that localized vaccinia virus (VACV) skin infection generates long-lived non-recirculating CD8+ skin TRM cells that reside within the entire skin.