Brexanolone - StatPearls - NCBI Bookshelf
2023年6月12日 · Brexanolone is a medication used in the treatment of postpartum depression in adult women. It is in the GABA-A modulator class of medications. This activity describes the indications, contraindications, pharmacodynamics, pharmacokinetics, and monitoring for brexanolone as a valuable agent in treating postpartum depression.
Allopregnanolone - Wikipedia
Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. [10][11] As a medication, allopregnanolone is referred to as brexanolone, sold under the brand name Zulresso, [6][12] and used to treat postpartum depression. [11][13][14] It is given by injection into a vein. [11][6]
Brexanolone Injection: MedlinePlus Drug Information
Brexanolone injection is used for the treatment of postpartum depression (PPD) in adults. Brexanolone injection is in a class of medications called neurosteroid antidepressants. It works by changing the activity of certain natural substances in the …
Brexanolone (intravenous route) - Mayo Clinic
2024年1月31日 · Brexanolone injection is used to treat postpartum depression (unusual physical, emotional, and behavioral changes in women after giving birth). This medicine is available only under a restricted distribution program called Zulresso® REMS (Risk Evaluation and Mitigation Strategy) Program. This product is available in the following dosage forms:
Brexanolone: Uses, Interactions, Mechanism of Action - DrugBank …
2016年10月20日 · Brexanolone is a neuroactive steroid that occurs naturally (referred to as natural allopregnanolone) in the body when the female sex hormone progesterone is metabolized 7. This steroid compound is also believed to exhibit activity as a barbiturate-like, positive allosteric modulator of both synaptic and extrasynaptic GABA (a) receptors Label 7, 9.
Treat Postpartum Depression | ZULRESSO® (brexanolone) CIV
ZULRESSO® (brexanolone) is an FDA-approved treatment for postpartum depression (PPD) in individuals 15 and older. ZULRESSO is administered continuously by intravenous infusion (into the vein) over 2.5 days (60 hours).
Brexanolone injection in post-partum depression: two multicentre ...
2018年9月22日 · Administration of brexanolone injection for post-partum depression resulted in significant and clinically meaningful reductions in HAM-D total score at 60 h compared with placebo, with rapid onset of action and durable treatment response during the study period.
Brexanolone to Treat Postpartum Depression in Adult Women
ZULRESSO (Brexanolone) is a novel FDA-approved treatment for moderate-to-severe postpartum depression. Postpartum depression may be diagnosed in women experiencing depressive symptoms which can manifest as cognitive, behavioral, or emotional ...
Bench-to-bedside: NIMH research leads to brexanolone, first-ever …
2019年3月20日 · Now, the U. S. Food and Drug Administration (FDA) has approved brexanolone, an analog of the endogenous human hormone allopregnanolone and the first drug specifically designed to treat postpartum depression.
Brexanolone - Memorial Sloan Kettering Cancer Center
What is this drug used for? It is used to treat postpartum depression (PPD). What do I need to tell my doctor BEFORE I take this drug? If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have kidney disease.