β-Lactam antibiotic - Wikipedia
The first β-lactam antibiotic discovered, penicillin, was isolated from a strain of Penicillium rubens (named as Penicillium notatum at the time). [4] [5] Bacteria often develop resistance to β-lactam antibiotics by synthesizing a β-lactamase, an enzyme that attacks the β-lactam ring.
13.3C: Beta-Lactam Antibiotics- Penicillins and Cephalosporins
2024年11月23日 · The principal antibiotic families of which the β-lactam ring is part of the core structure are the penicillins, cephalosporins, carbapenems, and monobactams, which are also called β-lactam antibiotics.
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
2023年6月4日 · These antibiotics (most of which end in the suffix - cillin) contain a nucleus of 6-animopenicillanic acid (lactam plus thiazolidine) ring and other ringside chains. The group includes natural penicillins, beta-lactamase-resistant agents, aminopenicillins, carboxypenicillins, and ureidopenicillins. Cephalosporins.
Beta lactam antibiotics - microbewiki
5 天之前 · Alexander Fleming isolated the first β-lactam antibiotic, penicillin, in 1929 from a strain of Penicillium rubens (fig. 1). His accidental discovery of the drug revolutionized the treatment of bacterial infections; this class is now the most commonly prescribed injectable antibiotic in …
β-Lactam - Wikipedia
The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics. Nearly all of these antibiotics work by …
Penicillin: Types, Structure-activity Relationship - Science Info
2023年8月18日 · Penicillin and other beta-lactam antibiotics have a four-membered beta-lactam ring. By binding the beta-lactam ring to D-transpeptidase, penicillin kills bacteria by preventing cross-linking and reducing cell wall production.
Overview of Beta-Lactams - Infectious Diseases - Merck Manual ...
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes.
Medicinal Chemistry of Beta-Lactam Antibiotics - PharmaFactz
Penicillin consists of a fused a β-lactam ring and a thiazolidine ring; part of the heterocyclic bicyclic system is the β-lactam ring. The bicyclic system confers greater ring strain on the β-lactam ring, an aspect important for activity. An amide and a …
β-lactam antibiotics: An overview from a medicinal chemistry ...
2020年12月15日 · The β-lactam antibiotics is a family of bactericidal drugs structurally-related containing the β-lactam ring in their chemical structure. They are classified in penicillins, cephalosporins, carbapenems, penems (also known as thiopenems) and monobactams.
Penicillins, Cephalosporins, and Other β-Lactam Antibiotics
2017年3月16日 · The basic structure of penicillins consists of a thiazolidine ring connected to β-lactam ring which is attached to a side chain (R). The β-lactam ring is the chief structural requirement for biological activity; loss of this structure will lead to loss of all the significant antibacterial activity.