BRCA Gene Changes: Cancer Risk and Genetic Testing
BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
肿瘤医生应该知道的生物标志物之：BRCA1/2 - 知乎
brca1/2作为一种重要的生物标志物，其检测有助于鉴别罹患卵巢癌、乳腺癌、胰腺癌以及前列腺癌等恶性肿瘤的高风险患者，并且能够评估患者预后、辅助治疗决策制定，本文就brca1/2在临床中的应用、风险评估以及检测平台等作一详细解读。
BRCA1 and BRCA2 Mutations - StatPearls - NCBI Bookshelf
2023年7月23日 · BRCA1 carriers have a worse overall survival than BRCA2 patients . Studies do show that women who carry BRCA mutations are more likely to develop secondary cancer - either in the same breast or the contralateral breast.
BRCA：乳腺癌的第一号导火索 - 知乎 - 知乎专栏
2019年11月5日 · 乳腺癌易感基因(breast cancer susceptibility gene,BRCA)——与乳腺癌有着密不可分的关系。BRCA基因的两个成员，即BRCA1和2，分别是在1990年和1994年被分离提取出来。
BRCA1 and BRCA2 gene mutations and cancer risk - Susan G.
2024年6月6日 · Women who have a BRCA1 or BRCA2 (BRCA1/2) inherited gene mutation have an increased risk of breast cancer and ovarian cancer. Estimates of these risks vary greatly. Women who have a BRCA1/2 inherited gene mutation have more than a 60% chance of getting breast cancer in their lifetimes and a 10%-60% chance of getting ovarian cancer [2].
关于BRCA1/2，你想知道的九个问题 - 知乎 - 知乎专栏
brca1/2的某些突变增加了女性乳腺癌和卵巢癌的风险，它们也增加其他一些癌症的风险。 总的来说，BRCA1/2的突变与约20-25%的遗传性乳腺癌发病相关，在所有乳腺癌发病中，它们的因素占5-10%。
基于下一代测序技术的BRCA1/2基因检测指南（2019版） - 中华病 …
brca1/2基因是评估乳腺癌、卵巢癌和其他相关肿瘤发病风险的重要生物标志物，也是影响患者个体化治疗方案选择的生物标志物，所以brca1/2基因检测具有重要的临床意义。
BRCA1- and BRCA2 -Associated Hereditary Breast and Ovarian Cancer
1998年9月4日 · In a recent randomized, double-blind Phase III trial, olaparib also improved progression-free survival in individuals with early, high-risk, human epidermal growth factor receptor 2-negative BRCA1- and BRCA2-associated breast cancer in …
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Prostate Cancer Screening and Surveillance for BRCA1/2 Carriers. For more information, see the Screening in carriers of BRCA pathogenic variants section in Genetics of Prostate Cancer. Management Guidelines for BRCA1/2 Carriers
BRCA1/2 Mutations and Breast/Ovarian Cancer Risk: A New
2024年8月6日 · This narrative review provides a comprehensive analysis of studies conducted between 1994 and June 2024, focusing on the link between specific mutations in the breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) and the associated risks of both breast and ovarian cancers.