Structural basis of AMPK regulation by adenine nucleotides and …
2014年11月21日 · Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05...
Structure of mammalian AMPK and its regulation by ADP
2011年3月13日 · We have determined the crystal structure of an active AMPK complex. The structure shows how the activation loop of the kinase domain is stabilized by the regulatory domain and how the kinase...
Mammalian γ2 AMPK regulates intrinsic heart rate - Nature
2017年11月2日 · Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and...
protein kinase AMP-activated non-catalytic subunit gamma 2
The IUPHAR/BPS Guide to Pharmacology. protein kinase AMP-activated non-catalytic subunit gamma 2 - AMPK subfamily. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
Structure and Physiological Regulation of AMPK - MDPI
2018年11月9日 · Here we provide an overview of AMPK structures, and how these structures, in combination with biochemical, biophysical, and mutational analyses provide insights into the mechanisms of adenine nucleotide binding and AMPK activity modulation. 1. AMPK Is a Master Regulator of Energy Homeostasis That Is Dysregulated in Disease.
Protein Structure and Folding - ScienceDirect
2008年6月27日 · We propose a structural model involving a ligand-induced relative movement of the kinase domain resulting in a more compact heterotrimer and a conformational change in the kinase domain that protects AMPK from dephosphorylation of …
Structure
2014年8月5日 · In this work, we provide the full-length structure of the widely expressed α1β1γ1 isoform of mammalian AMPK, along with detailed kinetic and biophysical characterization. We characterize binding of the broadly studied synthetic activator A769662 and its analogs.
Structural Insights into the Architecture and Allostery of Full …
2011年4月13日 · AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of α catalytic subunit, β scaffolding subunit, and γ regulatory subunit with critical roles in maintaining cellular energy homeostasis.
Structure and Physiological Regulation of AMPK - PubMed
2018年11月9日 · Here we provide an overview of AMPK structures, and how these structures, in combination with biochemical, biophysical, and mutational analyses provide insights into the mechanisms of adenine nucleotide binding and AMPK activity modulation. Keywords: AID; AMPK; CBS; CaMKK2; LKB1; activation loop; energy metabolism; α-linker; αRIM; β-linker.
51422 - Gene ResultPRKAG2 protein kinase AMP-activated non …
2024年11月2日 · AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes.