HDACs are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. HDACs can be divided into two categories, Zn 2+...

A physiological role of enzyme acetylation in mediating cellular adaptation to different metabolic fuels was suggested by the different growth properties of wild-type, ∆pat, or ∆cobB strains grown on different carbon sources .

Here, the authors highlight the diverse roles of acetylation and show that G6PD acetylation can activate/deactivate G6PD, and promote G6PD ubiquitylation and phosphorylation, its interaction...

Protein acetylation occurs through a nucleophilic acyl substitution reaction between a nucleophile and an activated acetyl group (CH 3 CO-X), which is typically in the form of acetyl coenzyme A (AcCoA) or acetyl phosphate (AcP) . This catalytic reaction can occur either chemically (nonenzymatically) between an acetyl donor and a protein or ...

Acetylation regulates the amount of metabolic enzymes. Acetylation can regulate the steady-state levels of metabolic enzymes by promoting their degradation through either the ubiquitin–proteasomal system in the case of phosphoenolpyruvate carboxykinase (PCK1; A) or CMA in the case of PK M2 isoform (PKM2; B).