BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and ...
2024年7月24日 · BDNF’s neuroprotective effects were observed in the primary motor cortex following a T9 spinal cord injury and the transplantation of mesenchymal stem cells modified to release BDNF. Assessment of the count of fluorogold-labeled corticospinal neurons indicated that BDNF could effectively rescue these neurons in comparison to T9 lesioned ...
Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in ...
2016年9月19日 · Research has extended to examine how spinal cord injury (SCI) influences BDNF plasticity and the effects BDNF has on sensory and motor functions after SCI. Functional recovery and adaptive plasticity after SCI are typically associated with upregulation of BDNF.
BDNF: the career of a multifaceted neurotrophin in spinal cord injury
Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter of neurite growth, a finding that has led to an ongoing exploration of this neurotrophin as a potential treatment for spinal cord injury. BDNF's many effects in the nervous system make it an excellent candidate for neu …
Sustained delivery of neurotrophic factors to treat spinal cord injury
BDNF binds to tyrosine kinase receptor B (TrkB), induces TrkB phosphorylation and activation of intracellular signaling pathways, reduces apoptosis of spinal cord motor neurons, and elevates the expression of 5-hydroxytryptamine at the injury site.
Neuromodulatory Effect of BDNF in Spinal Cord Injury
2023年9月21日 · The neuromodulatory effect of brain-derived neurotrophic factor (BDNF) in spinal cord injury (SCI) is a topic of significant interest. BDNF, a neurotrophic factor, plays a crucial role in promoting neuronal survival, axonal growth, and synaptic plasticity in the central nervous system.
The activation of BDNF reduced inflammation in a spinal cord injury ...
2018年12月18日 · In an in vitro model, overexpression of BDNF induced the protein expression of tyrosine kinase receptor B (TrkB) and suppressed that of phosphorylated (p-)p38, and reduced inflammation, as indicated by tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-18, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 levels.
Complete spinal cord injury (SCI) transforms how brain derived ...
2017年2月1日 · BDNF inhibits the development of spinally-mediated central sensitization after SCI. Acute spinal cord injury induces a qualitative shift in how BDNF affects nociceptive transmission. SCI modifies how BDNF affects the Cl − co …
Neuromodulatory Effect of BDNF in Spinal Cord Injury
2023年9月21日 · BDNF, a neurotrophic factor, plays a crucial role in promoting neuronal survival, axonal growth, and synaptic plasticity in the central nervous system. In SCI, BDNF has been shown to enhance...
Spinal Plasticity and Behavior: BDNF‐Induced Neuromodulation in ...
2016年9月19日 · Research has extended to examine how spinal cord injury (SCI) influences BDNF plasticity and the effects BDNF has on sensory and motor functions after SCI. Functional recovery and adaptive plasticity after SCI are typically associated with upregulation of BDNF.
BDNF Spinal Overexpression after Spinal Cord Injury Partially …
2022年11月8日 · The effect of AAV-BDNF injection into the lumbar L1-2 spinal segment on (A) BDNF mRNA and (B) TrkB mRNA levels in the L3-6 spinal segments, TA, and Sol motoneurons and muscles 2 weeks after spinal cord transection. BDNF and TrkB mRNA levels were measured with a qPCR assay.