Cortical microstructural associations with CSF amyloid and pTau
2023年12月13日 · Cortical dMRI measures, but not cortical thickness measures, were more widely associated with Aβ 1–42 than pTau 181 and better distinguished Aβ+ from Aβ- participants than pTau+ from pTau-...
Biomarker modeling of Alzheimer’s disease using PET-based
2022年4月25日 · We used PET-based Braak stage to model the trajectories of amyloid-β, phosphorylated tau (pTau) in cerebrospinal fluid (pTau181, pTau217, pTau231 and pTau235) and plasma (pTau181 and pTau231 ...
Phosphorylation of different tau sites during progression of …
2018年6月29日 · Our results suggest that the ptau burden in the isocortex is comparable between all analyzed ptau sites when using a quantitative approach while levels of ptau at Tyr18 or Thr231 in the transentorhinal region are different between all Braak stages.
Normalization of CSF pTau measurement by Aβ - BioMed Central
2020年8月15日 · Extracellular amyloid-β (Aβ) peptides in cortical Aβ plaques and intracellular phosphorylated tau protein as neurofibrillary tangles are key hallmarks of Alzheimer’s disease (AD) that can be measured in vivo with positron emission tomography (PET) imaging and biofluid markers including plasma and cerebrospinal fluid (CSF) assays.
Hypothesis: Tau pathology is an initiating factor in sporadic …
2020年10月19日 · Monkey data show phosphorylated tau (pTau) trafficking early in association cortex; pTau traps amyloid precursor protein-containing endosomes, which may increase Aβ and drive vicious cycles
Early and selective localization of tau filaments to glutamatergic ...
2024年6月11日 · At stage I, ptau is observed in the entorhinal cortex (EC), followed by the hippocampus at stage II. By stage III, ptau is located in other areas of the medial temporal lobe and is associated with amyloid-ß plaques and mild cognitive impairment.
Emerging signs of Alzheimer-like tau hyperphosphorylation and ...
2024年9月29日 · We first examined the level of phosphorylated tau (pTau) in the hippocampus and medial entorhinal cortex (MEC), since these regions play pivotal roles in the development of AD, and have been well-recognized to be vulnerable for pTau accumulation and neurodegeneration (Braak et al., 2006). Tau species ranging from 35 to 100 kD and phosphorylated ...
The influence of APOEε4 on the pTau interactome in sporadic
2024年5月21日 · A characterization of Tau pathology in the frontal cortex showed a higher density of plaque-associated neuritic crowns, made of dystrophic axons and synapses, in APOEε4 carriers. Cerebral amyloid angiopathy was more frequent and severe in APOEε4/ε4 cases. Our study supports an influence of APOE genotype on pTau-subcellular location in AD.
Relationships between plasma biomarkers, tau PET, FDG PET, and ...
2024年7月9日 · Plasma pTau-181 and GFAP correlate with tau PET, most strongly in left inferior temporal cortex (p = 0.0002, p = 0.0006, respectively). In regions beyond temporal cortex, tau PET uptake decreased with age for the same pTau-181 or GFAP concentrations.
Landscape of brain myeloid cell transcriptome along the …
2024年4月1日 · To capture myeloid cells along the stereotypical progression of tau pathology, we selected 5 brain regions that included allocortex and neocortex, from expected high to low pathology: entorhinal cortex (EC), inferior temporal gyrus (ITG), prefrontal cortex (PFC), visual association cortex (V2), and primary visual cortex (V1) (Fig. 1a).