Artemisinin: Could It Be a Cancer Treatment? - WebMD
2024年6月9日 · Some people believe that artemisinin may be an alternative to more aggressive cancer treatments. While cancer cells often become resistant to most chemotherapy drugs, that doesn’t seem to...
Artemisinin as an anticancer drug: Recent advances in target ... - PubMed
We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with regards to artemisinin target proteins and pathways, new understandings in artemisinin-induced cell death mechanisms, as well as the practical issues of repurposing artemisinin.
Artemisinins as Anticancer Drugs: Novel Therapeutic Approaches ...
Artemisinin induces selective and potent anticancer effects in drug resistant breast cancer cells by inducing cellular apoptosis and autophagy and G2/M cell cycle arrest. J. buon 25, 1330–1336. [ PubMed ] [ Google Scholar ]
Artemisinin compounds sensitize cancer cells to ferroptosis by ...
2019年5月21日 · We found that ART compounds, including dihydroartemisinin (DAT), an ART derivative with high bioavailability, can enhance the sensitivity of cancer cells to ferroptosis induced by both cysteine...
Artemisinin: A Promising Adjunct for Cancer Therapy - PMC
Artemisinin is a herb derived from Artemesia annua (also known as sweet wormwood) and is known for its use as effective antimalarial pharmacotherapy. Recent studies have shown that artemisinin has anti-angiogenic and growth inhibition effects, as well as an apoptotic ability secondary to its inherent endo-peroxidase activity.
The Real Cytotoxic Effect of Artemisinins on Colon Cancer Cells in …
2021年9月26日 · Artemisinin (ART) and dihydroartemisinin (DHA) are anti-malaria drugs but also exhibit huge anticancer potential based on ferroptosis driven by iron-dependent lipid peroxidation.
Repurposing Artemisinin and its Derivatives as Anticancer Drugs: …
Artemisinin and its derivatives have anticancer effects against multiple cancer types. because they act through various pathways, although their potency varies across cancer types. Their efficacy has also been demonstrated in in vivo studies with evidence of inhibition of tumor growth in tumor bearing mice models.
Artemisinin and its derivatives in cancer therapy: status of …
This article reviews the status of progress of artemisinin and its derivatives as anti-cancer agents in clinical trials, case reports, and in vitro/in vivo studies. Particular attention is laid on the combinations of artemisinins and synthetic chemodrugs to enhance the latter’s efficacy.
Artemisinin compounds sensitize cancer cells to ferroptosis by ... - PubMed
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation. Mechanistically, dihydroartemisinin (DAT) can induce lysosomal degradation of ferritin in an autophagy-independent manner, increasing the cellular free iron level and ...
Artemisinins as Anticancer Drugs: Novel Therapeutic Approaches ...
2020年10月6日 · Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging evidence for their excellent antitumor activities.