Anti-CTLA-4 nanobody as a promising approach in cancer
2024年1月8日 — In addition to low molecular weight, specific binding to targets, resistance to temperature, pH, and enzymes, high ability to penetrate tumor tissues, and low toxicity make nanobodies an ideal...
Nanobody: A Small Antibody with Big Implications for Tumor …
Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size (~15kDa), excellent solubility, superior stability, ease of manufacture, quick clearance from blood, and deep tissue penetration, which gain increasing acceptance as therapeutical tools and are considered also as buildin...
Enhancing Tumor Immunotherapy by Multivalent Anti‐PD‐L1 Nanobody …
2024年3月16日 — The nanobody-ferritin nanoplatform, by integrating the efficacy of PTT and immunotherapy, effectively ablated primary treated tumors, inhibited the growth of untreated tumors, and reduced metastasis of lung tumors, demonstrating the potential of …
Nanobody-based cancer therapy of solid tumors - PubMed
In this article, we describe factors that affect their performance at three different stages: their systemic circulation upon intravenous injection; their extravasation and tumor penetration; and, finally, their interaction with target molecules.
Nanobodies: Next Generation of Cancer Diagnostics and …
2020年7月22日 — However, the recent discovery of “nanobodies,” the smallest-known functional antibody fragment, has demonstrated significant translational potential in preclinical and clinical studies. This review highlights their various applications in cancer and analyzes their trajectory toward their translation into the clinic.
Nanobodies in cell-mediated immunotherapy: On the road to fight cancer …
Nanobodies can redirect immune cells to attack tumor cells through a chimeric antigen receptor (CAR) incorporating a nanobody against the target antigen. Various cancer antigens have been targeted by nanobody-based CAR-T and CAR-NK cells for …
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new
2023年9月4日 — A novel bispecific T-cell engager (BiTE) has been developed as an efficient immunotherapeutic molecule specifically bringing the T-cell and the tumor target together for enhanced immunotherapy.
Simultaneous selection of nanobodies for accessible epitopes on …
2023年11月17日 — We demonstrate biological parallel selection of enriched nanobodies for multiple immune cell subsets in the TME simultaneously. We then identified a nanobody enriched from dendritic cells (DCs)...
Nanobody: a promising toolkit for molecular imaging and disease …
2021年1月19日 — Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseases.
Frontiers | Editorial: Nanobody-based cancer immunotherapy and ...
2023年5月15日 — Targeting tumor cells with engineered T and NK cells harboring nanobody-based chimeric antigen receptors (CARs) has been discussed as the most successful application of nanobodies in cell-mediated immunotherapy. Also, authors reviewed the different nanobody-based strategies used to enhance anti-tumor functions of macrophages.