A common property of signalling receptor endocytosis is the efficient sorting ... by ligands that dissociate from them in endosomes. The EGFR agonist TGFα, for example, is released from the ...

These targets included (1) Insulin-like Growth Factor 2 Receptor (IGF2R), which is found in most tissues and triggers endocytosis through receptor dimerization, (2) Asialoglycoprotein Receptor ... As ...

Specifically, lower activation of the epidermal growth factor receptor (EGFR) signaling pathway occurs following reduced endocytosis. Decreased EGFR pathway activity allows LECs to switch from ...

Results: The expression of EGFR, a member of the receptor tyrosine kinase (RTK) family, was significantly increased in acquired regorafenib-resistant HCC cells compared with parental cells.

EGF receptor (EGFR) and HER2 are two members of the ErbB/HER-family of tyrosine-kinase receptors that are frequently altered in breast cancer and several other malignancies, which inspired the ...

“This increased our interest in the epidermal growth factor receptor (EGFR) pathway because previous work indicated that it may be regulated by endocytosis.” Using various molecular and ...

A new BLA for Dato-DXd targets EGFR-mutated NSCLC, following withdrawal of a previous application based on TROPION-Lung01 trial data. The new submission is supported by phase 2 TROPION-Lung05 trial ...