A common property of signalling receptor endocytosis is the efficient sorting ... by ligands that dissociate from them in endosomes. The EGFR agonist TGFα, for example, is released from the ...

Specifically, lower activation of the epidermal growth factor receptor (EGFR) signaling pathway occurs following reduced endocytosis. Decreased EGFR pathway activity allows LECs to switch from ...

These targets included (1) Insulin-like Growth Factor 2 Receptor (IGF2R), which is found in most tissues and triggers endocytosis through receptor dimerization, (2) Asialoglycoprotein Receptor ... As ...

"This increased our interest in the epidermal growth factor receptor (EGFR) pathway because previous work indicated that it may be regulated by endocytosis." Using various molecular and cellular ...