Hepatocellular carcinoma (HCC) is a significant global health issue, ranking as the sixth most prevalent malignancy and the ...

Surrounding these epithelial cells is a microenvironment of supporting ... effects on lymphocytes and indirectly by tuning tumor-associated macrophages function.

封底插图： 在肿瘤内部恶劣的环境中，膀胱癌细胞（喻为 红鱼 ）通过释放趋化因子CCL2来吸引巨噬细胞（喻为黑鱼）。作为响应，巨噬细胞释放细胞因子IL-6，辅助肿瘤细胞的增殖和干性维持，形成了一种促进肿瘤恶性生长的共生关系。这种互作关联揭示了肿瘤微环境中细胞间复杂的相互作用，也凸显了肿瘤进展中的关键调控机制。

Scientists uncover how disrupted lipid metabolism fuels chronic inflammation in colorectal cancer, offering insights into new ...

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in ...

In a study published in Cell Reports Physical Science on Nov. 25, a research team reported the development of an innovative ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

The interactions between cells in the tumor microenvironment (TME) are critical to tumor initiation, progression, metastasis and therapeutic responses. As a key target in cancer research and ...

In recent years, the tumor microenvironment (TME ... is densely populated by protumoral glioma-associated microglia and macrophages (GAMs),” the researchers found. “Myeloid immune checkpoint ...

About Pilatus Biosciences Inc.: Pilatus Biosciences is pioneering in discovering and developing first-in-class antibodies and ...