Notch signaling and epithelial-to-mesenchymal transition (EMT). Transformed, recruited and differentially activated cells surrounding the tumor form the tumor microenvironment. These cells inhibit ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

We are focusing on the regulation of growth and phenotype in embryonic and metastatic stem cells, mesenchymal cells and immune cells in the tumor microenvironment. The work incorporates signal ...

RANKL may induce EMT, which endows cancer cells with motility and invasiveness, and with the ability to enter systemic circulation. In the target site, cancer cells grow via a vicious cycle.