The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest ... 3’ dideoxy and 5’-phosphate termini but cannot catalyze adenylation of the 5’-end. Thus, ...

Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

“So, the combination of structural data, EM data and single-molecule studies provided three powerful ... Advances in understanding DNA repair will be an important step to developing new ...