The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest ... 3’ dideoxy and 5’-phosphate termini but cannot catalyze adenylation of the 5’-end. Thus, ...

Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is promoted through repair of these lesions by a ...

Apurinic/apyrmidinic endonuclease 1 (APE1) plays a central role in DNA repair by cleaving ... it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic ...