The so-called tumor microenvironment (TME ... has come up with a range of TME-related targets, like TGF-β, Notch, etc., supporting cancer treatment and accelerating the R&D procedure of users.

ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as well as the immunosuppressive TGF-β ...

Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T ...

ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as well as the immunosuppressive TGF-β ...

The tumor microenvironment (TME) consists of various components, including cancer cells ... each other via various cytokines including TGF-β and TNF-α, which often induce tumor progression.

3- Kindlin-2 as a major regulator of the oncogenic signaling of TGF-β and cancer cell senescence: We also established Kindlin-2 as a major player in the modulation of the tumor microenvironment by ...

New research published in Cancer Cell suggests that ... It is suggested that the presence of transforming growth factor-β (TGFβ) in the tumour microenvironment prevents the generation of N1 ...

In its two lead cancer assets ... In 2018, researchers found TGF-β, which is elevated in the tumor microenvironment, reduces the ability of T cells to penetrate tumors, thereby reducing the ...

Its malfunctions cause developmental defects, immune disorders, fibrosis, and cancer. We defined a pathway in which TGF-β binds to receptor serine ... mesenchymal cells and immune cells in the tumor ...