These creams kill cancer cells when applied directly to the skin. The most commonly prescribed medication of this type is the antimetabolite 5-fluorouracil (Efudex, Carac). Because these topical ...

5-fluorouracil is a thymine analog. Via an unknown mechanism it acts selectively on AK dysplastic cells, causing apoptosis and destruction. Another advantage of this medication is that it allows ...

A database search of PubMed and Embase was performed from 1965 to April 2012 using the terms 'actinic keratoses', 'solar keratoses', 'topical 5-fluorouracil', 'topical 5-FU', 'double-blind ...

The findings could have a significant effect on how doctors treat many cancer patients. Usually, 5-fluorouracil is given in ...