In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the ...

The movie adaptation of Tomi Adeyemi's debut YA novel, Children of Blood and Bone, is officially on the horizon. After being years in the making, it looks like the literary phenomenon is finally ...

Osteolytic diseases, such as osteoporosis, rheumatoid arthritis, osteosarcoma, and giant-cell tumors of bone, are characterized by increased bone resorption and decreased bone formation, leading to ...

A recent study offering a comprehensive view of the genome and transcriptome of gastrointestinal stromal tumors (GISTs) has introduced a new, multi-omics-based molecular classification of these ...

Bone health may not be something you think about every day, but it's silently working behind the scenes to keep you strong and supported from the inside out. Below, experts explain why it’s ...

Chest wall tumors are benign or malignant growths that develop anywhere along your chest wall. Doctors use imaging tests and a biopsy to diagnose them. Surgery is often a needed treatment.

"We know how to cure primary tumors—with surgery ... skin-like cells (squamous), bone-like cells (osteoblasts), and cells that release hormones and communicate with the nervous system ...

"We know how to cure primary tumors -- with surgery ... skin-like cells (squamous), bone-like cells (osteoblasts), and cells that release hormones and communicate with the nervous system ...