However, NK cells in the tumor microenvironment often become functionally exhausted, characterized by decreased numbers and impaired functions due to imbalances in immune regulatory signals. This ...

1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts. 2Department of Immunology, Harvard Medical School, Boston, Massachusetts. 3Department of Neurology, ...

Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients ...

Some patients being treated with immune ... no evidence for T-cell receptors recognizing the α-myosin protein, which was previously reported to be a pivotal antigen driving checkpoint myocarditis.

Nov. 26, 2024 — A new study has uncovered an unexpected way cancer cells can escape the immune system, making it harder for treatments to work. The study explains how a type of cancer cell death ...

A widely accessible drug commonly used to control blood glucose levels in diabetic patients has the potential to strengthen the effects of immunotherapy and ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

In the past few years, immunotherapy, mainly immune checkpoint inhibitors (ICIs), has revolutionized the clinical strategy ... This review describes the immunosuppressive cell populations in the ...

His translational research program investigates the interaction of T-cell metabolism and radiotherapy, resistance to immunotherapies, and fundamental mechanisms underlying the role of the immune ...