These overburdened endosomes respond by releasing mtDNA into the cell – in short, the trash can overflows. "We had a huge breakthrough when we saw that mtDNA was inside of a mysterious membrane ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...