Metoprolol can interact with several medications, including certain blood pressure drugs, monoamine oxidase inhibitors (MAOIs ...

The authors postulated that this was probably related to greater inverse agonist activity and more pronounced negative inotropic effects of metoprolol.

There is evidence to indicate that full adrenergic blockade by carvedilol improves survival and cardiovascular outcome in patients with heart failure compared with metoprolol treatment ...