Based on these data, we conclude that the failure of RAD50 to enter the nucleus and resect meiotic DSB is the primary defect in phs1 mutants. A model for meiotic prophase regulation by controlling ...

Meiotic chromosome segregation relies on synapsis and crossover (CO) recombination between homologous chromosomes. These processes require multiple steps that are coordinated by the meiotic cell cycle ...

In combination with previous work, we establish Mer2 as a keystone of the DSB machinery by bridging key protein complexes involved in the initiation of meiotic recombination. Using a combination of ...