In this animal, challenged intravenously, anaphylactic shock is believed to be due to liberation of histamine with subsequent contraction of smooth muscle. Contraction of the bronchial musculature ...
Studies of aetiology have focused on risk factors such as childhood adversity and life events; information on the nature and circumstance of symptom onset may shed light on the mechanism of symptom ...
The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...
An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
Determinants such as the heterogeneity of the latent reservoirs and the complexity of epigenetic, transcriptional, and post-transcriptional molecular mechanisms regulating HIV-1 latency largely ...
From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...
The defects in molecular and cellular processes that constitute the triggers of specific pathologies are referred to as mechanisms of disease. Research in this area is vital for designing ...
Immunopathological Mechanism of PMOP. B cells differentiate into osteoclasts ... Additionally, estrogen downregulates hypoxia-inducible factor-1α expression by upregulating heat shock protein 70 ...