A standard treatment for mastocytosis is difficult to apply to individual patients based on the variable clinical course. A general consensus for using antimediator agents such as antihistamines ...

Here, we examined the effect of chronic stress on colonic permeability and the participation of mast cells in this response. METHODS Mast cell deficient Ws/Ws rats and +/+ littermate controls were ...

The lesions in TMEP are not pruritic and do not produce Darier's sign because mast cell proliferation may not be sufficient to produce significant degranulation (Alto & Clarcq, 1999; Hogan & Lewis ...

umin.ac.jp Objective Extracellular ATP mediates mast cell-dependent intestinal inflammation via P2X7 purinoceptors. We have previously shown that CD300f (also called the leucocyte ...

Keywords: Chronic inducible urticaria; cold urticaria, cholinergic urticaria, contact urticaria, delayed pressure urticaria, immunoglobulin E, mast cells, patient-reported outcomes, provocation ...

The drug, an oral Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, was designed to inhibit mast cell degranulation to ease CSU symptoms. Celldex's shares saw a significant increase ...

Nov. 27, 2024 — The food additive carrageenan (E 407) can be responsible for the development of chronic inflammatory bowel disease, ulcers, and increased blood sugar levels in animals ...

Established in 2016, the Human Cell Atlas (HCA) consortium set out to create a comprehensive biological map of cells within the human body. Now progressing into a data integration phase ...