Lactate exerts immunosuppressive effects by regulating the functions of various immune cells (such as natural killer cells, T cells, dendritic cells, and monocytes) and its role in macrophage ...

Specifically, lactic acid suppresses T cells and prevents immune cells from reaching the tumor. Lactic acid generates a low pH level in the tumor microenvironment that makes it difficult for immune ...

Tito A. Sandoval; Camilla Salvagno; Chang-Suk Chae; Deepika Awasthi; Paolo Giovanelli; Matias Marin Falco; Sung-Min Hwang; Eli Teran-Cabanillas; Lasse Suominen ...

Using lactic acid for skin care can help you have a smoother, brighter complexion. As a gentle alpha hydroxy acid (AHA), lactic acid removes dead skin cells, lightens dark spots, and improves the look ...

Interestingly, these processes are all sensitive to the concentration of oxygen present in the microenvironment. Rapidly proliferating cells cause the NSCLC tumor to extend beyond the oxygen ...

The novel human cancer models comprising tumor microenvironment (TME), such as tumor organoids and organs-on-a-chip, has been established in recent years to help elucidate the underlying mechanisms of ...

1Ellison Institute of Technology, Los Angeles, CA.

Chronic pancreatitis is a risk factor for the development of pancreatic cancer. Here authors report that coxsackievirus and adenovirus receptor (CAR) expression promotes pancreatitis and ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...