A conventional strategy for identification of disease genes is to use microarrays to compare the level of gene-specific mRNA expression between patient and control samples. Inter-individual ...

近年来，mRNA疗法展现出独特优势和巨大潜力，在肿瘤治疗新药开发与临床应用领域成为全世界的研究热点。2023年，诺贝尔生理学或医学奖授予mRNA技术的两位奠基人——卡塔琳·考里科和德鲁·韦斯曼。 “mRNA技术的可行性、快速响应能力与大规模生产能力已得到 ...

Our data and analyses provide a useful resource to study spatiotemporal gene expression regulation. Transcriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear ...

Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

Egr-1 has been linked with atherogenesis, myocardial ischemia-reperfusion injury, cardiac fibrosis and heart failure. Egr-1 expression is triggered by a host of factors including cytokines, hormones, ...

Badyal et al. showed that the loss of CD44 in IMPC is correlated with LNM, indicating its potential as a marker to predict LNM. This phenomenon is attributed to the re-expression of CD44 in lymph ...