In addition to this list, there are a number of constructs that can be classified as an expression but do not follow any general syntax rules. These generally have the semantics of a function or ...

近年来，mRNA疗法展现出独特优势和巨大潜力，在肿瘤治疗新药开发与临床应用领域成为全世界的研究热点。2023年，诺贝尔生理学或医学奖授予mRNA技术的两位奠基人——卡塔琳·考里科和德鲁·韦斯曼。 “mRNA技术的可行性、快速响应能力与大规模生产能力已得到 ...

Our data and analyses provide a useful resource to study spatiotemporal gene expression regulation. Transcriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear ...

Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

Single-cell RNA sequencing reveals a profound loss of myofibroblasts in two models of BPD and identifies gene expression signatures of increased TGFβ signaling, cell cycle arrest, and impaired ...

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States David H Koch Institute for Integrative Cancer Research, Massachusetts Institute ...

Methods: The expression of adhesion molecules such as: fibronectin, vimentin, focal adhesion kinase (FAK), integrin 1β, integrin α5, E-cadherin, and molecules involved in neovascularization processes ...

Background: Integrin subunit alpha L (ITGAL) is crucial for activating CD8 + T cells through magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might exert an important ...