Chronic activation of the cGAS-STING pathway may promote inflammatory states that exacerbate insulin resistance and lipid accumulation, forming a feedback loop of metabolic dysfunction. This review ...

Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, ...

However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, ...

A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

In 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain's outer cortical cells that produces a novel 'graded' signal all on its own, one that could provide ...

The patient would then join the pathway after the first diagnostic test (labelled on this pathway diagram as ‘straight to one-stop clinic’). The National Cancer Waiting Times Monitoring Dataset ...

Leptin and Insulin Resistance Pathway Convergence At the cellular level, leptin signaling intersects with insulin pathways in pancreatic β-cells. When leptin binds to its receptors in these cells ...

This can disrupt insulin signaling pathways, a sign of insulin resistance. • Poor diet: Consuming a poor-quality diet high in processed foods, refined carbohydrates, and sugary beverages ...

clang-uml is an automatic C++ to UML class, sequence, package and include diagram generator, driven by YAML configuration files. The main idea behind the project is to easily maintain up-to-date ...

In a mixed-sex population of Drosophila larvae, IIS activity is positively regulated by nutrient availability to promote growth (Böhni et al., 1999; Britton et al., 2002; Chen et al., 1996; Fernandez ...

Mullapudi et al. used these mutant offspring to screen over 2,000 drugs for their ability to decrease blood sugar levels in the absence of insulin. The screen identified three promising candidate ...