Keywords: high-order chromatin organization, gene regulation, TADs, LADs, NADs, eukaryotes Important note: All contributions to this Research ... who are already familiar with their journal's scope, ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

we estimated fluxes of ribosomes on the 5′ UTRs of two identified DENR-dependent model transcripts, Klhdc8a and Asb8, and addressed the effect of penultimate codon identity. Ribosome profiling from ...

Upon deletion of the ALAS2 gene, the researchers subsequently observed classic symptoms of XLSA like anemia and enlargement of the spleen. The model also allowed the researchers to note features ...

At the University of Utah, scientists used a new gene therapy that was shown to reverse the effects of heart failure in a large animal study. In the study, pigs with heart failure were found to ...

The course focuses on current understanding of the structure and function of eukaryotic transcription factors. Topics covered are: promoters, RNA polymerase II, general transcription factors and ...

Upon deletion of the ALAS2 gene, the researchers subsequently observed classic symptoms of XLSA like anemia and enlargement of the spleen. The model also allowed the researchers to note features of ...

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Our study also highlights the importance of gene regulation in the evolution of the OhyA protein family ... The evolutionary history of OhyA in Bacillales provides a valuable model for understanding ...