Figure 1: Delivery of synthetic shRNA into Nanog-GFP mouse ES cells. M15 ES cell medium with leukemia inhibitory factor (LIF): DMEM Knockout (Gibco), 15% fetal bovine serum (FBS; StemCell ...

Here, we report the genotypes and phenotypes of heteroplasmic MT-ND5 gene-knockout mice. These mutant mice presented damaged mitochondrial cristae in the cerebral cortex, hippocampal atrophy, and ...

Endocannabinoids, molecules naturally produced in the brain, play a critical role in regulating appetite, energy use, and ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas ...

Mitochondria possess their own DNA (mtDNA), which plays important roles in cellular respiration and energy consumption.

With Gene Editing, Mice With a Form of Inherited Deafness Can Hear Again July 12, 2024 — Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss.

Conditional alleles may be given priority when knockout alleles ... at the gene expression level. Finally, we note that introducing experimental envirotypes into mouse phenotyping protocols ...

This study investigates the role of Aff3ir-ORF2, a novel nested gene variant, in disturbed flow-induced endothelial cell activation and atherosclerosis. We demonstrate that disturbed shear stress ...

Gene therapy that selectively delivers the SMN1 gene to the liver reduced alterations related to spinal muscular atrophy (SMA) in a mouse model, restoring muscle size and correcting pancreatic issues.

Scientists explore how daily glucocorticoid signaling influences glioblastoma growth and synchronizes its circadian rhythms ...

Various forms of blood cancer exist—all of which are grouped together under the term leukemia. One common form of leukemia is ...