Although fewer antibody fragments have entered the clinic ... completed clinical study of any type), whereas six bispecific Fab candidate fragments have been discontinued. Twenty-four fragments ...

HILIC-MS lets free thiols in mAb processing be localized directly and quantified at domain-specific resolution.

(A) The structure of a monoclonal antibody, such as infliximab, adalimumab or golimumab, and (B) the structure of certolizumab. Fab: Antibody-binding fragment of immunoglobulin; Fc: Constant fragment.