Then, they used advanced microscopy to see the molecules that link epithelial cells and observe how a lack of FXR affects the intestinal barrier in the presence of disease. The lack of this ...

Extrarenal production of active vitamin D in immune cells is ... cells through the FXR. Secondary bile acids that are byproducts of metabolism of primary bile acids by intestinal bacteria induce ...

which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice ...