State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, ...

spectrophotometric analysis at 482 nm can be used to quantify the activity of β-lactamase, which hydrolyzes the antibiotic nitrocefin. This system can therefore be used to monitor the enzyme’s ...

There are several potential β-lactamase inhibitors under ... Representative enzyme(s) A 2a Penicillins Greater hydrolysis of benzylpenicillin than cephalosporins PC1 A 2b Penicillins, early ...

This valuable study describes how a single effector of the Type Six Secretion System (T6SS) has two distinct enzymatic functions that together may contribute to bacterial survival and dynamics in a ...

Third generation cephalosporins were the highest consumed class of antibiotics across the years followed by combinations of beta-lactams and beta-lactamase inhibitors. Though the Reserve group ...

The paper addresses an important unresolved mechanism of antibiotic resistance caused by a RNA-modifying enzyme Cfr, a protein that confers resistance to multiple ribosome-targeting antibiotics due to ...

Beta-lactamase provides antibiotic resistance by breaking down the antibiotics’ structure. Another cause for worry is that over 78% of the bacteria were multi-drug resistant, according to the ...