In animal cells, DNA can be modified by methylation of cytosine residues in CpG dinucleotides, and the N-terminal tails of histone proteins are subject to a wide range of different modifications ...

DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine ...

PE is thought to result from a combination of factors, including inflammatory cytokines, trophoblast dysfunction, and environmental influences, which may trigger epigenetic changes, particularly DNA ...

A new study introduces a method to infer DNA methylation patterns in non-skeletal tissues from ancient DNA, offering insights into human evolution, particularly brain function. Using an algorithm with ...

More importantly, studies of DNA methylation and histone modification using NGS technologies have yielded new discoveries and improved our knowledge of human biology and diseases. The concept that ...

This genetic change can either be induced by a change in the DNA code (mutation) or a change that does not affect the genetic code but instead influences the way this code can be read. The latter is ...

This study would be of interest to biologists in the fields of epigenetics and metabolism. Maternal obesity has deleterious effects on the process of establishing oocyte DNA methylation; yet the ...

Inspired by natural epigenetic inheritance, the researchers designed a system in which fragments of DNA, called bricks, assemble to form a unique pattern. Each of these bricks is made up of 24 ...

They then succeeded in stably modifying bases on the DNA carrier by selective methylation ... but currently only changes individual cytosine building blocks according to the epigenetic model ...

One cubic centimeter of DNA could theoretically hold up to ... Each of these bricks is made up of 24 nucleotides (including cytosine sites for methylation) and encodes one bit of information ...