In animal cells, DNA can be modified by methylation of cytosine residues in CpG dinucleotides ... bind to the gene promoter region and turn off transcription. This form of repression seems ...

DNA methylation is the covalent addition of ... with consequences for the binding of regulatory proteins such as transcription factors. SOX-OCT binding site and CTCF binding site 3 in H19-ICR ...

PE is thought to result from a combination of factors, including inflammatory cytokines, trophoblast dysfunction, and environmental influences, which may trigger epigenetic changes, particularly DNA ...

Plant biologists like Aman Husbands at the University of Pennsylvania study a family of skilled subcontractors, known as the HD-ZIPIII transcription factors (TFs). These subcontractors are tasked ...

Python script to quickly extract promoter and terminator regions with the NCBI API. Search for the presence of individual pattern or transcription factor responsive elements with manual sequence ...

More importantly, studies of DNA methylation and histone modification using NGS technologies have yielded new discoveries and improved our knowledge of human biology and diseases. The concept that ...

This manuscript reports important findings on the impact of maternal obesity on oocyte methylation and its transgenerational effects ... Outside-to-in: chromosome, hyper-DMRs, TE (transcription end ...

TSS (transcription start site), TES (transcription end site), UTR3 (3’ end untranslated region), and UTR5 (5’ end untranslated region) regions (Fig. S2A), and the average methylation levels of DMRs in ...

Bladder cancers comprise heterogeneous cell populations, and numerous factors are likely to be involved in dictating recurrence, progression and patient survival. While several molecular markers ...

CAG, cytosine-adenine-guanine. CRC, colorectal cancer; iAR, intracellular androgen receptor; mAR, membrane androgen receptor. Figure 4. The intestinal microecological dysregulation-induced ...

Demographic factors such as age, race, or gender, as well as genetics, also appear to play a role in suicidal ideation and completion, though in some cases the root cause of their influence is ...

One way that gene expression can be modified is through the activity of transcription factors. These proteins recognize and bind to small stretches of DNA near the genes, called regulatory elements.