In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

For the first time, researchers have discovered that the accumulation of aged and failing cells, called senescent cells, in ...

When a telomere attains a critical short length, cells recognize it, and replication is attenuated, which results in cell senescence. Previous studies have indicated that magnesium maintains telomeric ...

Dr. Sajad Zalzala, chief medical officer of AgelessRx in Michigan, helps people live their longest, healthiest lives. He ...

Subsequently, the function and molecular mechanism of GKN1 was explored in vitro and in vivo. Results It was shown that GKN1 is an autocrine/paracrine protein and inhibits cell growth due to ...

Wounds take time to heal but in older adults the time taken may be longer An expert explains why and steps one can take to speed up recovery ...

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including ...

We have developed molecules in each of these classes for treatments of hematologic and solid tumors, virally infected cells, ...

Enhancing our understanding of the heterogeneity of senescence in vivo, Gasek et al. identify a distinct and detrimental p21 highly expressing cell population induced upon wound healing.

By examining nine mouse tissues, researchers pinpointed specific regions — known as senescence-sensitive spots (SSSs) — characterized by cellular disarray and a buildup of immunoglobulins. This ...

Scientists from CAS and BGI Research found that immunoglobulins are both drivers and markers of aging, with IgG accumulation ...