Pulmonary arterial hypertension (PAH) is associated with impaired metabolism and reduced NAD levels that contribute to its hyperproliferative state. CD38 is an ecto-enzyme that degrades NAD and ...

Using enzyme assays and in vitro and in vivo metabolic assays, we demonstrate that sUA directly inhibits the hydrolase and cyclase activities of CD38 via a reversible non-competitive mechanism, ...

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Here, we demonstrate that sUA at physiological levels directly inhibits CD38 and consequently limits NAD + degradation and excessive inflammation, which defines, for the first time, the physiological ...

FK866 potently inhibited NAMPT activity as demonstrated by reduced mucosal NAD, resulting in reduced abundances and activities of NAD-dependent enzymes including PARP1, Sirt6 and CD38, reduced nuclear ...

Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States ...

In the pursuit of youthful aging and vitality, many individuals find themselves exploring various supplements and health ...

apoptosis in Keratinocytes. It is able to do this by translocating NAD+ glycohydrolase (SPN) across the target cells membrane. It then removes the N-terminal ...

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