利用合成致死（Synthetic Lethality）特异性杀伤肿瘤细胞，是近年来肿瘤临床治疗的一项重要尝试。特别是靶向 BRCA1/BRCA2 突变的 PARP 抑制剂（PARPi），自问世以来便展现出显著的临床疗效，为基于合成致死原理的靶向药物开发提供了积极的实践验证。 然而，PARPi 的 ...

Everyone has BRCA1 and BRCA2 genes, but people who have changes in the gene are at higher risk of certain cancers including cancers of the breast, ovaries, prostate and pancreas. Ethnicity can ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.