Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. DNA methyltransferase 3A (DNMT3A) plays a ...

研究人员发现，即使没有二次突变，单个错误的BRCA1拷贝也会使乳腺细胞更容易罹患癌症，并足以引发肿瘤生长。这项研究成果于2024年11月11日发表在《Nature Genetics》杂志上。 众所周知，我们从父母那里获得了每个基因的两个拷贝，这是进化过程中的一个防故障 ...

Iron uptake by plants is highly regulated, but the underlying mechanism is poorly understood. Using a truncated fragment of the iron deficiency-responsive bHLH100 gene promoter, we screened the ...

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1 ...

For cancer-suppressor genes like BRCA1, researchers have long hypothesized that a single healthy copy could still guard against tumor development. Yet women with one harmful BRCA1 mutation are far ...

“Our work provides an answer to what’s been a lingering question in the field. It shows why and how even a single defective copy of BRCA1 can alter cells in a way that accelerates cancer,” said study ...

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...