新研究表明在HER2阳性乳腺癌患者中，胚系BRCA1/2突变的发生率为6.6%，且不影响生存结果。乳腺癌是女性最常见的恶性肿瘤，遗传易感性作为其主要风险因素，在全部乳腺癌病例中占比达5%-10%。其中，约50%的病例与乳腺癌相关基因BRCA1和BRC ...

研究人员发现，即使没有二次突变，单个错误的BRCA1拷贝也会使乳腺细胞更容易罹患癌症，并足以引发肿瘤生长。这项研究成果于2024年11月11日发表在《Nature Genetics》杂志上。 众所周知，我们从父母那里获得了每个基因的两个拷贝，这是进化过程中的一个防故障 ...

据《美国医学会杂志》发表的研究披露，研究人员开展的一项分析包括了近1万名BRCA1 或 BRCA2基因变异的妇女，这项分析旨在估测有这些基因突变的 ...

Adjuvant Lynparza remains beneficial for patients with BRCA1/2 mutation–positive, HER2-negative high-risk breast cancer, study results have shown.

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

BRCA1 (breast cancer 1, early onset) is a tumor suppressor that probably has a DNA repair function. BRCA1 is expressed at high levels in the T cell lineage, however its function during thymocyte ...

Cancer researchers at Fox Chase Cancer Center in Philadelphia see promise in personalized medicine to help crack the code on ...

In recent years, her focus has shifted to oncology, where she has become a trusted voice in understanding genetic risks for ...

Adjuvant olaparib continued to show a strong efficacy benefit in patients with BRCA1/2 mutation–positive, HER2-negative ...

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of ...