The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ...

"After constructing AAVs with a cancer-specific promoter and a cancer-targeting nanoparticle, we found this therapy is very powerful to treat multiple cancers." Experiments in mouse models showed ...

Overall, this fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. The evidence supporting the ...

Tumor volume was measured and calculated using the formula: volume = length × width² × 0.5. All animal experimental procedures ... in vivo effect of squalene in the KPC syngeneic mouse model, and ...

The body's ability to respond to cellular stress is a critical mechanism for maintaining health. When cells undergo damage or ...

Ovarian cancer cells exploit cell competition by altering Flower protein isoforms in stromal cells, promoting tumor survival ...

Our previous reports have focused on the tumor microenvironment in liver cancer ... has been largely ineffective across multiple cancer models, suggesting that CXCR4 targeting should be tested ...

The models were developed using a training cohort of 761 patients with HR-positive, HER2-negative metastatic breast cancer who received first-line endocrine therapy with CDK4/6 inhibitor ...

A new study suggests certain lipids, particularly omega-6 fatty acids, which are commonly found in seed oils used to make ultraprocessed junk food, may promote inflammation that can lead to colon canc ...

New research reveals the role that sausage, breads, and even ice cream play in cancer growth. Science has already linked ultra-processed foods to heart disease, inflammation, diabetes, and cancer.