There are three phase transitions in a cell cycle: G1/S to initiate DNA synthesis, G2/M to enter mitosis, and metaphase/anaphase to exit mitosis. Different models of cell cycle regulation ...

Prometaphase is an extremely dynamic part of the cell cycle. Microtubules rapidly assemble ... only cells with correctly assembled spindles enter anaphase. The progression of cells from metaphase ...

The membrane around the nucleus disappears. Metaphase Chromosomes and their copies line up in the middle of the cell. Anaphase Chromosomes and their copies are pulled to different ends of the cell.

The high selectivity and temporal control of these chemical-genetic systems were crucial in revealing new roles of each kinase throughout the cell cycle. For instance, acute inhibition of Plk1 at ...