Figure 4: The N-terminal repressor domain of REST is TSA-sensitive. Figure 6: TSA increased the association of acetylated histone H3 and H4 with GluR2 promoter in C6 glioma but not cortical neurons.

With histone deacetylases (HDACs) inhibited, acetylated histones cause DNA relaxation, allowing tumor suppressor genes to be accessible for transcription (right). Illustrated by Taina Litwak ...

Fluctuation ('noise') in gene expression is critical for mammalian cellular processes. Numerous mechanisms contribute to its origins, yet the mechanisms behind large fluctuations that are induced by ...

Hdac6 localizes to promoters bound by Tip60-p400 in ESCs, binding downstream of transcription start sites. Surprisingly, Hdac6 does not appear to deacetylate histones, but rather is required for Tip60 ...

HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and ...